1580 HYPERTHERMIA-INDUCED SEIZURES IN THE RAT PUP
نویسندگان
چکیده
منابع مشابه
Lipopolysaccharide potentiates hyperthermia-induced seizures
BACKGROUND Prolonged febrile seizures (FS) have both acute and long-lasting effects on the developing brain. Because FS are often associated with peripheral infection, we aimed to develop a preclinical model of FS that simulates fever and immune activation in order to facilitate the implementation of targeted therapy after prolonged FS in young children. METHODS The innate immune activator li...
متن کاملTransient hyperthermia protects against subsequent seizures and epilepsy-induced cell damage in the rat.
Many mild preconditioning stress conditions, including physical and metabolic injuries, increase the resistance of neurons to subsequent more severe stresses of the same or different type. This "tolerance phenomenon" lasts one to several weeks, providing a unique opportunity to investigate endogenous neuroprotective mechanisms. The aim of this study was to find a physiological and easily applic...
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It has been described that febrile seizures during infancy increase risk of subsequent non-febrile seizures during the adulthood. However, latency period between febrile seizure and the onset of the first spontaneous seizure has not been evaluated. The present study was designed to investigate the susceptibility to subsequent seizures in immature rats that had experienced early-life hyperthermi...
متن کاملIncrease in rat pup ultrasonic isolation calls induced by lindane.
The neurotoxic agent lindane was tested for its ability to alter the rate of ultrasonic isolation calls of suckling rats. Doses that did not produce any sign of convulsant activity significantly increased the number of calls and the cumulative time of calling in male pups. At days 10-13 of age after a single dose of 20 mg/kg lindane, animals showed more than twice the control call values. After...
متن کاملEffect of intracerebroventricular injection of COX-1 inhibitor (ketoprofen) on PTZ-induced seizures in male rat
Introduction: Ketoprofen is an NSAID and selective COX-1 inhibitor. In our previous study the role of flunixin meglumine, a nonselective COX inhibitor was studied on seizure and its anticonvulsant effects were confirmed. Therefore this research is performed to assess the role of a selective COX-1 inhibitor, ketoprofen in treatment of seizures induced by PTZ. Methods: In this research, male ...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1981
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198104001-01597